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In brief, it is suggested that an elevated secretion of pro-inflammatory cytokines and diminished hepatoprotection by IL-6 might contribute to TVX-induced hepatotoxicity in the model, whereas the non-DILI reference drug LVX did not alter the cytokine profiles

Maher EA, Marin-Valencia I, Bachoo RM, Mashimo T, Raisanen J, Hatanpaa KJ, et al

This section discusses MS pathogenesis with emphasis on neuroinflammation and BBB disruption, the roles of dysfunctional innate immune cells, adaptive T and B cell dysregulation, and the resultant pathological outcomes

doi: 10.1016/j.bbrc.2003.10.075 58 AdamouJHeinrichsJErwinAWalshWGayleTDormitzerMet al