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10.1515/dmdi.2001.18.3-4.159 6 AjayiB.AdedaraI

2.3 Dysregulation of mitophagy The accumulation of fragmented and dysfunctional mitochondria resulting from excessive fission imposes a critical burden on the mitophagic clearance system

The content is not intended to encourage application, diagnosis, or self-treatment of unlicensed individuals, and should not be used as a substitute for the clinical judgment of a qualified healthcare provider.

Importantly, most biological damages caused by RCS are related to -dicarbonyls (compounds with two adjacent reactive carbonyl groups), including glyoxal, methylglyoxal, 3-deoxyglucosone, 3-deoxyfructose