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Discussion As one of the most complex biological processes that occur during human life, the wound repair process involves four steps that include inflammation around the site of injury, angiogenesis and the development of granulation tissue, repair of the connective tissue and epithelium, and ultimately remodeling that leads to a healed wound

Periodontal osseous defects in 25 patients treated with combination of anorganic bovine-derived hydroxyapatite matrix and P-15 showed favourable clinical results [109]