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Vitamin D and calcium are also needed to prevent and treat the bone problems that often occur

Studies have shown that the usual effect produced by adding corticosteroids is inhibition of response to coumarins, although there have been some conflicting reports of potentiation not substantiated by studies

Factors that may influence protocol design include: The nature and location of the injury Activity level and physical demands Age and recovery history Concurrent treatments or medications Clinicians such as those affiliated with Pulse and Remedy emphasize that peptide protocols should evolve over time, with adjustments based on patient response and ongoing evaluation

JAMA Psychiatry 70 , 4958 (2013)