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This strong, synergistic effect was also observed in murine MLL-AF9/ Nras G12D-driven leukemia cells (RN2) 35 (Supplementary Fig

We measured the levels of mTOR phosphorylation at Ser2448, and the mTOR target protein 49 , the ribosomal protein S6 kinase (p70S6K) phosphorylation at Thr389, which indicates the mTORC1 activity