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This triggers broken immune tolerance: Overactivated innate immune cells secrete pro-inflammatory cytokines, CD4 + T cells skew toward pro-inflammatory subsets (T-helper 1 [Th1] cells/Th17), T regulatory cell (Treg) function is impaired, and autoantibodies exacerbate inflammation

Ronen O, Robbins KT, Olsen KD, Shaha AR, Randolph GW, Nixon IJ, Zafereo ME , Hartl DM, Kowalski LP, Rodrigo JP, Coca-Pelaz A, Mkitie AA, Vander Poorten V, Sanabria A, Angelos P, Rinaldo A, Ferlito A

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54,55 Given the increases in patient satisfaction and treatment engagement without significantly worsening outcomes, the above legislation continues to gain bipartisan support as opioid-related fatalities increase nationwide