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The available evidence is preclinically solid but limited in human medicine to a single field of application

The abuse of rhGH by athletes to improve performance is also a major concern, and underscores the need for new and more specific biomarkers of GH action [3-7]

Its very short half-life makes it a "natural mimetic" molecule, particularly suited to research protocols on the physiological GH axis

When injected, it binds to GHRH receptors on the pituitary and triggers a pulse of growth hormone release, which in turn drives the production of IGF-1 (insulin-like growth factor 1), the downstream hormone responsible for most of growth hormones tissue effects