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Indian Journal of Psychological Medicine, 34 (3), 255-262

Mitochondrial quality control is determined not only by lysosomal competence but also by the cytoskeletal architecture that spatially organizes mitochondria, autophagosomes, and lysosomes within PACs

This process involves an initial priming step, in which damage-associated molecular patterns (DAMPs), recognized by TLR-4, stimulate the expression of IL-1, IL-18, and NLRP3 through the activation of NFB pathway