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199,200,201 Although some pharmacological approaches using IGF1 have shown protective effects against cardiac injury and dysfunction in animal experimental studies, 202,203 clinical trials reported that chronic administration of IGF1 to human participants did not confer significant cardioprotective effects and may even cause cardiac fibrosis

Int J Pharmaceut

[Abstract] Oncogene

The Kendalls tau analysis found positive correlations that were significantly different from 0 in the HC group, for cross-pathway purine and monoamine metabolite pairs ( Table 2 ) as follows: (1) for UA with TRP, 5-HIAA, MEL, KYN, and TYR