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Science 358 , 623630 (2017)

For example, the Carotene and Retinol Efficacy Trial (CARET), a study of beta-carotene and retinyl palmitate supplementation, was stopped prematurely due to an increase in lung cancer risk and death from lung cancer in participants who received the intervention [109]

Research has shown that IGF-1 can reduce the accumulation of toxic proteins, such as beta-amyloid plaques in Alzheimer's disease, and enhance the clearance of these proteins from the brain

In the SAH mouse model, BRD4 can impede the generation of A1 subtype astrocytes by inducing Pan-Kla and H4K1la, thereby providing protection for neuronal survival [57]