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Good sleep hygiene consistent bedtime, minimal bluelight exposure, stress reduction, and avoiding stimulants before bed will enhance the effects of DSIP (or any sleep promoting substance) far more than simply boosting dose

Other studies show that calcium oxide crystals induce mitochondrial dysfunction in macrophages.[ref][ref] High dietary oxalate intake causes some, but not all, people to have statistically significant decreases in mitochondrial metabolic function.[ref] Animal models of high oxalate levels show that there is an increase in mitochondrial reactive oxygen species (ROS) that can lead to oxidative stress if glutathione is inadequate

Patch clamp electrophysiology studies showed significantly increased synapse density in hippocampal tissue

even with weight loss of 1 kg