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doi: 10.1007/s12325-022-02081-w

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These include insufficient drug specificity, difficulties in achieving efficient mitochondrial delivery, the delicate balance between therapeutic dosage and toxicity, and variability in patient responses due to individual differences

also demonstrated that Asn levels are increased in activated CD8 + T cells and bind to the SRC family tyrosine kinase LCK, assisting in the phosphorylation of LCK at Tyr394 and 505, enhancing LCK activity and T-cell receptor signaling