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The attention for this compound was drawn by the findings of Carlton that cuprizone possesses various biotoxic effects in rodents like growth retardation, pregnancy disturbances, and severe CNS pathology, including demyelination, astrogliosis, and hydrocephalus (Carlton, 1966, 1967, 1969)

Neurobiol Dis 152:105276 Parkes I, Chintawar S, Cader MZ (2018) Neurovascular dysfunction in dementia - human cellular models and molecular mechanisms

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