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Eric Topol of Scripps Research Translational Institute was more direct: "These peptides have no data to support their safety and efficacy." The clinical proponents argue that the FDA's safety concerns immunogenicity risk, impurity risk, organ toxicity are theoretically valid but speculative in practice

Surgeries Some stomach or intestine-related surgeries can also reduce the bodys ability to absorb vitamin B12 effectively

These effects may be attributed to the suppression of oxidative stress (by increasing SOD, CAT, and GSH-Px activities and reducing MDA levels in the cortex and hippocampus of diabetic mice) and regulating acetylcholinesterase activity in the brain (65)

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