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Since ghrelin promotes gastrointestinal motility in addition to GH release, the prokinetic effect of a selective ghrelin mimetic is biologically plausible and consistent with the rodent data from Venkova et al., 2009

Modulation is typically mild but significant in the setting of hyperprolactinemia

Patients receiving tirzepatide and sermorelin together require enhanced monitoring protocols beyond standard care for either medication alone, given the absence of established safety data for this combination

Studies demonstrate that ipamorelin-induced increases in growth hormone and IGF-1 levels can help counteract these age-related changes