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It has demonstrated the ability to selectively affect multiple intracellular signaling pathways and contributes to regulating protein aggregation, mitochondrial function, and nitrosative or oxidative stress [99]

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However, given that erastin was lethal to various cells, including some that lack mutant HRAS, the data were re-analyzed in order to look for targets bound by active erastin-A6 (but not inactive erastin-B2) in both cells types, as follows

Krabbe (stored galactosylceramide) using targeted enzyme replacement therapy with galactocerebrosidase