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Alterations in expression of genes regulated by estrogens associate with an increased risk for metabolic liver diseases: LDLR [59, 60], APOA5 [61] and ABCA1 primarily in women, and LIPC in men [58]

Its reduced form, GSH, serves as a potent redox buffer, shielding our DNA, cell lipids, and proteins from the damaging effects of free radicals and peroxides, which can harm cell structures and disrupt metabolic processes

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TNF- and IL-6 have been shown to downregulate AQP2 transcription and impair vasopressin receptor sensitivity through JAK/STAT and SOCS signaling, further diminishing renal responsiveness