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The compound has served as a biochemical tool to probe how NNMT activity intersects with insulin signaling and glucose utilization pathways in research settings

Dual mechanism addresses both insulin and glucagon pathways

Nevertheless, use of metformin may decrease vitamin B 12 status: a meta-analysis of four short-term intervention trials (up to 4 months duration) in patients with type 2 diabetes found that metformin use decreased serum cobalamin concentrations by 57 pmol/L, which could have clinical implications if such patients have suboptimal vitamin B 12 status (146)

In this topic, we discuss some major symptoms that indicate deficiency of vitamin b12 in dogs