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GLP-1 drugs already carry a significant GI side-effect burden, and adding a supplement that independently irritates the stomach or alters motility can compound the problem

Mechanism investigation focuses on Akt-eNOS axis activation and sustained NO synthesis for neovascularization

However, they should still avoid St John's wort and exercise caution with supplements that may affect bleeding risk

Iron chelating agent DFP is commonly used in the treatment of thalassemia syndrome patients, effectively reducing serum ferritin, and increasing transferrin saturation, and is well-tolerated