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The energy of this process, in which electrons are transferred from the substrates of the TCA to oxygen, is coupled to vectorial transport of H + from the mitochondrial matrix space [22]

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Intestinal microbiota plays a crucial role in regulating the integrity of the intestinal barrier and host wellbeing, and maintaining a healthy gut environment necessitates stability in terms of species composition, abundance, and localization

So if someone is low in B12 and they consume alcohol, they not only don't have enough B12 to help 'clear away' the alcohol toxins but they also risk increasing homocysteine levels which I believe is that feeling of heat/hangover that can persist when there isn't enough B12 to reset the body