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Biallelic lossoffunction mutations in SEPTIN4 (C17ORF47), encoding a conserved annulus protein, cause thin midpiece spermatozoa and male infertility in humans

Neovascularization involves several growth factors and cytokines, such as fibroblast growth factor (FGF), platelet-derived endothelial cell growth factor (PD-ECGF), angiopoietin (Ang)1/2, matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9), among which vascular endothelial growth factor (VEGF) is the most vital irritant

Peroxynitrite is documented to be highly injurious, and its reduction yields neuroprotection following experimental TBI and ischemia reperfusion (IR) injury [35, 4042]