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the resulting mucosal injury and inflammation closely resemble mechanisms in acidosis 90,91,92

Momtazi-Borojeni AA, Haftcheshmeh SM, Esmaeili SA, Johnston TP, Abdollahi E, Sahebkar A (2018) Curcumin: a natural modulator of immune cells in systemic lupus erythematosus

2-HG affects cellular metabolism, enhances the oxidation of NADPH in NADP+ which, in turn, disrupts cellular homeostasis and increases the level of ROS (112)