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Despite evidence of systemic iron and ROS accumulation in FRDA, whether neuronal loss is directly mediated by ferroptosis remains an open question requiring further mechanistic exploration

This is due partly to cumulative effects of oxidative stress, which can damage DNA and impair oocyte viability

The field of peptide therapy has a history of issues and abuses of medical power, such as the Verkow triad, and it is essential to be cautious when introducing new interventions to patients, with the primary goal of doing no harm 10s

The past 10 years, however, have seen the development of enzyme therapy for arginase deficiency and gene therapy for ornithine transcarbamylase deficiency