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, ID 1 mg/kg :3 5(0.15%), 50 mg/kg ( 5).In the second rat ID study, the most effective permeation enhancer (PE) tested for a 1 mg/kg dose of SEQ ID NO: 3 peptide was a combination of 50 mg/kg sodium kenodeoxycholate and 25 mg/kg propyl gallate Was found, which increased the oral bioavailability of the SEQ ID NO: 3 peptide by about 20-fold to 0.39% (Table 6)

Canela VH, Bowen WS, Ferreira RM, Syed F, Lingeman JE, Sabo AR et al (2023) A spatially anchored transcriptomic atlas of the human kidney papilla identifies significant immune injury in patients with stone disease