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Phosphorylation of the DSGIS motif in NRF2 mediated by glycogen synthase kinase-3 beta (GSK-3) promotes the binding of -TrCP to NRF2 which is therefore marked for ubiquitination and then degraded by the proteasome [145, 149,150,151]

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This gene plays a critical role in: Converting folate into usable forms Supporting methylation Transforming homocysteine into methionine Producing glutathione, a vital antioxidant When this function is impaired, detoxification becomes more difficult, and nutrient absorption suffers

126 Exploration of the relationship between methionine metabolism, LSECs, and fibrosis regression may provide unexpected findings