DBCO-Dap(m-PEG4)-Val-Cit-PAB deuterium-labeled-ketone Nature Chem 5

Nature Chem 5

S)-AHPC-acetamido-O-PEG1-C2-Cl Synonyms CAS Number n/a Related CAS Molecular Formula C28H39ClN4O6S Molecular Weight 595

697 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCOCCOCCOCCOCC#C)CCN(CC(O)=O)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

349 Purity (HPLC) >= 95% Solubility DMSO

DBCO-Dap(m-PEG4)-Val-Cit-PAB deuterium-labeled-ketone Nature Chem 5SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a DBCO Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. DBCO is a strained alkyne commonly used in copper free click chemistry, specifically in the strain promoted azide alkyne cycloaddition (SPAAC) reaction. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG,