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MMPs mediate the degradation of collagen and other extracellular matrix components within the fibrous cap, thereby disturbing the dynamic balance of collagen synthesis and degradation that underlies plaque stability.When collagen degradation becomes relatively enhanced and compensatory synthesisprimarily mediated by vascular smooth muscle cellsis insufficient, the structural integrity of the fibrous cap may be compromised

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Sigma-Aldrich, H9268) in 6-well plates

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