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Following cellular uptake, cystine undergoes reduction to cysteine, primarily mediated by thioredoxin-related protein 14 (TRP14) through the dithiol-disulfide exchange (Mart-Andrs et al., 2024)

In this study we report on an oxaliplatin-based platinum(IV) prodrug, which releases L -buthionine- S , R -sulfoximine (BSO), an inhibitor of glutamate-cysteine ligase, the rate-limiting enzyme in GSH biosynthesis