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In 1999, Ross (6) proposed that AS is a chronic and progressive inflammatory disease, the mechanism of which involves endothelial cell dysfunction and lipid accumulation, and that AS is an important pathological cause of acute cardiovascular and cerebrovascular diseases

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(1) DOX was prepared at 2.16 mg/ml in a vehicle of 4.32% DMSO in saline, with 100 L per 27 g body weight, achieving a dose of 8 mg/kg, with control animals instead receiving a DMSO saline vehicle