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Spinal Muscular Atrophy SAPPHIRE SAPPHIRE was a randomized, double-blind, placebo-controlled Phase 3 clinical trial that evaluated the safety and efficacy of apitegromab in non-ambulatory patients with Types 2 and 3 SMA who are receiving current standard of care (either nusinersen or risdiplam)

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There are a couple of other scenarios in which acetaminophen is more likely to cause liver damage: Alcohol Use Disorder: Normally, alcohol is metabolized using the alcohol dehydrogenase enzymes, but in cases of chronic overconsumption or binge drinking, the CYP2E1 enzyme is upregulated to metabolize the extra alcohol

1 Introduction Amino acids are organic compounds containing both amino (NH 2 ) and carboxyl (COOH) groups