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Not only does the resulting barrier disruption promote diarrhoea because of increased water concentration in the intestinal lumen, but there is also a greater opportunity for the development of secondary infections due to deeper tissue penetration by other pathogens and toxins (Guttman and Finlay 2009)

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Proc Natl Acad Sci USA 87:79587962 Sanchez M, Galy B, Muckenthaler MU, Hentze MW (2007) Iron-regulatory proteins limit hypoxia-inducible factor-2 expression in iron deficiency