paracetamol glutathione depletion Too much = dangerous because of how your liver processes it. *Normal dose:* About 90-95% gets broken down safely by glucuronidation + sulfation → non-toxic stuff you pee out. *The problem Acetaminophen Toxicity: OPPOSITE EFFECTS OF
Acetaminophen Toxicity: OPPOSITE EFFECTS OF TWO FORMS OF GLUTATHIONE PEROXIDASE ScienceDirect Oxidative stress during acetaminophen hepatotoxicity: Sources, pathophysiological role and therapeutic potential ScienceDirect Reducing the effects of drug toxicity on glutathione metabolism ScienceDirect PharmGKB summary: Pathways of acetaminophen metabolism at the therapeutic versus toxic doses PMC
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