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)Deficiency in SAM leads to conditions such as poor sleep, poor maturation of the gut wall, and developmental delay due to lack of activation of neuronal stem cells and subsequent differentiation into myelin-producing oligodendrocytes in the brain

R-DHEA will stack well with 4-DHEA as it may help reduced water retention from under the skin, thus creating a dry and hard appearance

Ethics statement The requirement of ethical approval was waived by Ethics Committee of Chongqing Hospital of Traditional Chinese Medicine for the studies on humans because blood sampling, genetic testing and treatment of patients basically meet the requirements of treatment routine and guidelines