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doi: 10.1016/j.jdermsci.2019.10.004 109 SongC

FIGURE 4 3.3.1 Sirtuin activators Sirtuins also play important roles in regulating mitophagy for their deacetylation activity (Zhao N

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Preclinical studies indicate potential roles in: Supporting healthy fat metabolism and reduction of adipogenesis Improving insulin sensitivity in metabolic research models Enhancing NAD+ salvage pathway efficiency Exploring effects on energy homeostasis and longevity pathways These findings remain preliminary and confined to laboratory and animal models