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This process is primarily driven by the overexpression of COX-2 in OCSCs, which leads to an increased production of PGE2

Mol Neurobiol 59:74957512

3.1 Glucose metabolism Lactate is a necessary byproduct of glycolysis, and tumor cells in the TIME are extremely dependent on glycolytic capacity, excreting large amounts of lactate, resulting in a localized low glucose, low oxygen, and acidic environment