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Candidate metabolic trait GWAS with HGA/GR and MET/TYR ratios For 288 of the 290 subjects in this study we had genotype data for the Illumina human 610-Quad BeadChips (Illumina, San Diego, CA, USA) available, as described previously 38,41

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In Na + titration experiments, saturating concentrations of carnitine were applied to oocytes expressing hOCTN2 and mutants (1150 mM NaCl, 150 mM - [NaCl] CsCl, 2 mM KCl, 1 mM MgCl 2 , 1.8 mM CaCl 2 , 5 mM HEPES, buffered to pH 7.4 with Tris base)