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D.Effect of purified rat and hamster hepatic glutathione S-transferases on the microsome mediated binding of aflatoxin B1 to DNA.Cancer Lett.;1 EOF9 EOF1986 32

Studies on glucose metabolism and insulin secretion conducted in p43 knockout mice with preserved expression of other THs receptors have revealed impaired insulin and glucagon secretion by the pancreas, with no effect of glucose on insulin secretion, decreased density of the islets of Langerhans, reduced expression of GLUT2 and Kir 6.2 protein - a subunit of the ATP-dependent K+ channel (32)

175 For the PPP enzymes, recent studies have discovered some inhibitors targeting on G6PD, such as NADP + analogs, the competitive inhibitor 6-aminonicotinamide (6-AN), noncompetitive inhibitors epiandrosterone and dehydroepiandrosterone (DHEA) which reduces the availability of NADPH and inhibits the cell growth

2020), as well as in a placebo-controlled, dose-ranging study in 29 PD patients, including subgroups with and without LRRK2 mutation (NCT03710707), according to a press release (Therapeutics 2020)