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Additionally, variants associated with other facets of AD, namely lipid and lipoprotein processing, are becoming increasingly implicated in AD onset and severity

Enrichment analysis was performed

In negative ion mode (Supplementary Figure 2), the metabolite with the highest increase in the DSS group was Glucoputranjivin (log2FC = 3.77), and the metabolite with the highest decrease was Piperonal (log2FC = 4.56)