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More than half of colorectal cancers (CRCs) harbor activating mutations in KRAS or BRAF, yet those cancers are the most refractory to current targeted therapies

In addition, the small molecular self-assembly prodrug ATRA-SS-ATRA (compound 6 ) was obtained from ARTA upon reaction with 2,2-disulfide diethanol by using 4-dimethylaminopyridine (DMAP)/triphosgene in 82.0% yield (Fig

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Glutathione is synthesized by the body itself, but from about 40 years of age and under oxidative stress, the glutathione content decreases sharply