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Both the AE and AE+N-CUR groups demonstrated a pronounced downregulation of TGF-1 in comparison to tumor control subjects, with the combined treatment exhibiting the most substantial effect

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Observations of GDAP1 H-site structure have shown that it adopts a fold consistent with the GST family (Googins et al., 2020

Because Arg67 is the ligand that directly interacts with MDSA, the R67A mutant demonstrated activity that was notably less inhibited by MDSA, with an IC 50 value of 185 M, which was over 300-fold that of the WT (Table 1)