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Proposed Mechanisms (Preclinical) Cellular & Genomic Signaling Explored for modulation of telomerase activity and support of telomere-length maintenance in select cell-culture models

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Despite the limited number of targets and the emergence of resistance, which pose challenges for antifungal therapy, new drugs such as Ibrexafungerp (formerly known as SCY-078), Rezafungin, Fosmanogepix and Olorofim have shown promising clinical efficacy (Wiederhold, 2020

206 In addition, tissue-specific aging processes manifest distinct inflammaging signatures, with IL-17 predominating in cutaneous aging, IL-6 predominating in vascular aging, and TNF- predominating in immune organ senescence