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(2) Clinical or preclinical studies involving interventions based on HO-1 or its active metabolites (e.g., CO, biliverdin, bilirubin)

SchiattarellaGGSanninoAToscanoEGiuglianoGGargiuloGFranzoneAet al

Encyclopedia of systems biology

That parent protein, Body Protection Compound, is found naturally in human gastric juice, where it plays a reasonably well-established role in gastric cytoprotection