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JPEN J Parenter.Enteral Nutr 1990;14(4):428-430

NO helps counteract oxidative stress and is involved in the management of hypoxia-related disorders by improving erythrocyte deformability, thereby supporting more efficient oxygen delivery and better clinical outcomes ( Various protein kinases and phosphatases tightly regulate erythrocyte signal transduction, allowing rapid responses to hypoxia, metabolic shifts, oxidative stress, and shear forces

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4 Diagnosis is largely based on imaging with magnetic resonance cholangiopancreatography (MRCP)