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2.13.1.5 V717I (London mutation) Position 717 in the amyloid precursor protein (APP) is a well-established hotspot for mutations linked to autosomal dominant Alzheimers disease (ADAD)

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Vagal tone is reduced during paced breathing in patients with the chronic fatigue syndrome

Reversing these impairments could present potential treatment modalities against the rapid advancement of these diseases ( 2.6 Genetic factors Genetic mutations and polymorphisms can elevate the risk of developing neurodegenerative diseases