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In conclusion, rhamnetin exhibits a favorable safety profile at therapeutic doses, with potential adverse effects primarily associated with supratherapeutic levels

KLOW targets several stages of the healing cascade inflammation control, angiogenesis, collagen production, and cell migration simultaneously

Additionally, MSU crystals diminish intracellular NAD+ concentration by stimulating the nicotinamide adenine dinucleotide (NAD+) degrading enzyme (CD38) in macrophages, subsequently promoting IL-1 secretion (41)

has identified death of intestinal epithelial cells via necroptosis as a critical mechanism of intestinal barrier disruption during the onset of CIA [1]

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