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doi: 10.7554/eLife.30881 117 VeermanKTardiveauCMartinsFCoudertJGirardJP

Unmodified siRNAs are rapidly degraded by serum nucleases and trigger potent innate immune responses via toll-like receptor (TLR)3/7/8 and RIG-I activation, resulting in excessive type I interferon production [55]