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Proteostasis in cardiovascular health and disease Cardiovascular tissues, particularly the heart, operate under constant mechanical, metabolic and oxidative stress and therefore depend critically on robust proteostasis to sustain contractile function, bioenergetic efficiency and cellular survival

On the other hand, our 2-piece d-monobody synthesis strategy has the advantage that the C-terminal peptide contains the FG loop and the randomized library residues of the C/D strands, both major contributors to monobody-target binding, whereas the N-terminal peptide only contains that CD loop, which often is not involved in target binding

(2015), suggested that the regulation of oxidative stress by glycitin was related to the suppression of adipose tissue and the progression of diabetes

Its tolerability profile supports its use in patients with altered bowel motility, though we have no objective data confirming benefit in CIRS