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For example, high levels of GSH in the TME not only serve as a key defense line for tumor cells against oxidative stress and ferroptosis but can also directly chelate and inactivate specific metal ions (such as Cu 2 ), thereby weakening the effectiveness of therapeutic strategies based on metal-catalyzed reactions [161]

Neuronal oxidative injury and dendritic damage induced by carbofuran: protection by memantine

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To identify associations between chemical and physical edaphic factors and any treatment effects, distance-based linear modelling 66 was used to identify the best combination of edaphic factors to model the multivariate data