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You are allergic to cobalt

When it comes to the functioning of your cells, methyl groups are used in methylation reactions.[ref] Examples of methylation reactions include: synthesis of some of the nucleic acid (DNA) bases turning off genes so that they arent transcribed (DNA methylation) converting serotonin into melatonin methylating arsenic so that it can be excreted breaking down neurotransmitters metabolizing estrogen regenerating methionine from homocysteine Methylation in the right amount: For example, you need enough folate (vitamin B9) and methylcobalamin (vitamin B12) for the methionine synthase reaction to occur

First, the choice depends on the condition being treated

The researchers noted a clear dose-response relationship, where higher doses yielded better clinical outcomes, particularly in patients who carried variations in the MTHFR gene