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A recent preclinical study reported that a MUC1-based vaccine, when co-administered with a PD-L1 checkpoint inhibitor, significantly boosted tumor-specific CD8 T cell activation and suppressed tumor growth more effectively than monotherapies [247]

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Infante-Rivard C, Jacques L

There are multiple studies that highlight the various transcriptional and epigenetic factors that regulate SLC7A11 expression, however, further studies are required to understand whether SLC7A11 is also regulated via other mechanisms, especially post translational mechanisms and the existence of key interaction partners, etc